https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33086 Wed 15 Dec 2021 16:08:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18030 Wed 11 Apr 2018 14:49:14 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10728 0.05). There was greater motility of CD151-transfected vs. control cells, when transferring through migration chambers with or without matrigel-coated membranes (P<0.01, P<0.01). Fewer numbers of mutant-transfected cells were found on the membranes for both migration and invasion studies (P<0.01, P<0.01). CD151 knock-down PC3 cells showed decreased motility (P<0.01), but no change in proliferation (P>0.05). Our data show that CD151 does not change the proliferative properties of prostate cancer cells, but does promote migration and invasion, and suggest that CD151 plays a specific role in promoting prostate cancer cell motility.]]> Wed 11 Apr 2018 14:15:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14359 -ΔΔCt method was used to calculate the degree of expression. MTT assay showed the expression of miR-10b to have no effect on the proliferation of NPC cell lines. The wound healing assay showed that miR-10b mimics promoted the mobility and invasion of NPC cell lines. Inhibitors of miR-10b reduced the ability of NPC cell lines to migrate and invade. In addition, the expression of genes related to migration and invasion, such as E-cadherin, vimentin, and MMP-9, were confirmed to be different in the CNE-2Z NPC cell line transfected with miR-10b mimics and with miR-10b inhibitors. In the present study, miR-10b was found to upregulate the expression of MMP-9 and knockdown of miR-10b was found to significantly downregulate the expression of E-cadherin. On the whole, these results showed that miR-10b plays an important role in the invasion and metastasis of NPC cells.]]> Wed 11 Apr 2018 12:17:27 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13435 Wed 11 Apr 2018 12:07:36 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14383 Wed 11 Apr 2018 09:49:12 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44082 in vitro and orthotopic tumour growth in vivo. Dynamin inhibition reduced glioblastoma cell line viability and suppressed neurosphere formation and migration of GSCs. Tumour growth was reduced by CyDyn 4-36 treatment. Dynamin 2 inhibition therefore represents a novel approach for stem cell-directed Glioblastoma therapy.]]> Thu 06 Oct 2022 15:06:34 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25166 Thu 03 Feb 2022 12:22:19 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19089 Sat 24 Mar 2018 08:05:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20990 Sat 24 Mar 2018 07:50:42 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27080 Sat 24 Mar 2018 07:40:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39586 in silico using the Kaplan-Meier Plotter (n=3,935), the TCGA invasive breast carcinoma (n=960) and GOBO (n=821) data sets. Functional effects of BAALC expression on breast cancer proliferation, migration and invasion were determined in vitro. We demonstrate herein that BAALC expression is progressively increased in primary and breast cancer metastases when compared to normal breast tissue. Increased BAALC mRNA is associated with a reduction in DMFS and disease-free survival, but not OS, in breast cancer patients, even when corrected for tumor grade. We show that overexpression of BAALC in MCF-7 breast cancer cells increases the proliferation, anchorage-independent growth, invasion, and migration capacity of these cells. Conversely, siRNA knockdown of BAALC expression in Hs578T breast cancer cells decreases proliferation, invasion and migration. We identify that this BAALC associated migration and invasion is mediated by focal adhesion kinase (FAK)-dependent signaling and is accompanied by an increase in matrix metalloproteinase (MMP)-9 but not MMP-2 activity in vitro. Our data demonstrate a novel function for BAALC in the control of breast cancer metastasis, offering a potential target for the generation of anti-cancer drugs to prevent breast cancer metastasis.]]> Mon 08 Aug 2022 11:48:18 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41224 Fri 29 Jul 2022 10:25:19 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39954 Rhinella marina) and native water rats (Hydromys chrysogaster), where toads are novel prey. We show that wild water rats preferentially targeted larger toads, and consumed specific non-toxic organs only. Rats either rapidly learned these behaviours, or adapted them from hunting native frogs.]]> Fri 22 Jul 2022 11:49:25 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52684 Fri 20 Oct 2023 09:58:07 AEDT ]]>